Title: Regulatory assessment of chemical mixtures: requirements, current approaches and future perspectives
Authors: KIENZLER AUDEBOPP StephanieVAN DER LINDEN SANDERBERGGREN ELISABETWORTH Andrew
Citation: REGULATORY TOXICOLOGY AND PHARMACOLOGY vol. 80 p. 321-334
Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE
Publication Year: 2016
JRC N°: JRC100355
ISSN: 0273-2300
URI: http://dx.doi.org/10.1016/j.yrtph.2016.05.020
http://publications.jrc.ec.europa.eu/repository/handle/JRC100355
DOI: 10.1016/j.yrtph.2016.05.020
Type: Articles in periodicals and books
Abstract: This paper reviews regulatory requirements and recent case studies to illustrate how the risk assessment (RA) of chemical mixtures is conducted, considering both the effects on human health and on the environment. A broad range of chemicals, regulations and RA methodologies are covered, in order to identify mixtures of concern, gaps in the regulatory framework, data needs, and further work to be carried out. Also the current and potential future use of novel tools (Adverse Outcome Pathways, in silico tools, toxicokinetic modelling, etc.) in the RA of combined effects were reviewed. The assumptions made in the RA, predictive model specifications and the choice of toxic reference values can greatly influence the assessment outcome, and should therefore be specifically justified. Novel tools could support mixture RA mainly by providing a better understanding of the underlying mechanisms of combined effects. Nevertheless, their use is currently limited because of a lack of guidance, data, and expertise. More guidance is needed to facilitate their application. As far as the authors are aware, no prospective RA concerning chemicals related to various regulatory sectors has been performed to date, even though numerous chemicals are registered under several regulatory frameworks.
JRC Directorate:Health, Consumers and Reference Materials

Files in This Item:
There are no files associated with this item.


Items in repository are protected by copyright, with all rights reserved, unless otherwise indicated.