Title: Physico-chemical Properties of Manufactured Nanomaterials - Characterisation and Relevant Methods. An outlook based on the OECD Testing Programme
Authors: RASMUSSEN KIRSTENRAUSCHER HUBERTMECH AGNIESZKARIEGO SINTES JUANGILLILAND DOUGLASGONZALEZ MARKEARNS PETERMOSS KENNETHVISSER MAAIKEGROENEWOLD MONIQUEBLEEKER ERIC
Citation: REGULATORY TOXICOLOGY AND PHARMACOLOGY vol. 92 p. 8-28
Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE
Publication Year: 2018
JRC N°: JRC106653
ISSN: 0273-2300
URI: http://www.sciencedirect.com/science/article/pii/S0273230017303343?via%3Dihub
http://publications.jrc.ec.europa.eu/repository/handle/JRC106653
DOI: 10.1016/j.yrtph.2017.10.019
Type: Articles in periodicals and books
Abstract: Identifying and characterising nanomaterials require additional information on physico-chemical properties and test methods, compared to chemicals in general. Furthermore, regulatory decisions for chemicals are usually based upon certain toxicological properties, and these effects may not be equivalent to those for nanomaterials. However, regulatory agencies lack an authoritative decision framework for nanomaterials that links the relevance of certain physico-chemical endpoints to toxicological effects. This paper investigates various physicochemical endpoints and available test methods that could be used to produce such a decision framework for nanomaterials. It presents an overview of regulatory relevance and methods used for testing fifteen proposed physico-chemical properties of eleven nanomaterials in the OECD Working Party on Manufactured Nanomaterials' Testing Programme, complemented with methods from literature, and assesses the methods' adequacy and applications limits. Most endpoints are of regulatory relevance, though the specific parameters depend on the nanomaterial and type of assessment. Size (distribution) is the common characteristic of all nanomaterials and is decisive information for classifying a material as a nanomaterial. Shape is an important particle descriptor. The octanol-water partitioning coefficient is undefined for particulate nanomaterials. Methods, including sample preparation, need to be further standardised, and some new methods are needed. The current work of OECD's Test Guidelines Programme regarding physico-chemical properties is highlighted.
JRC Directorate:Health, Consumers and Reference Materials

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