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dc.contributor.authorKNAPEN DRIESen_GB
dc.contributor.authorANGRISH MICHELLE M.en_GB
dc.contributor.authorFORTIN MARIE M.en_GB
dc.contributor.authorKATSIADAKI IOANNAen_GB
dc.contributor.authorLEONARD MARCen_GB
dc.contributor.authorMARGIOTTA-CASALUCI LUIGIen_GB
dc.contributor.authorMUNN SHARONen_GB
dc.contributor.authorO’BRIEN JASONen_GB
dc.contributor.authorPOLLESCH NATHANen_GB
dc.contributor.authorSMITH L. CODYen_GB
dc.contributor.authorZHANG XIAOWEIen_GB
dc.contributor.authorVILLENEUVE DANen_GB
dc.identifier.citationENVIRONMENTAL TOXICOLOGY AND CHEMISTRY vol. 37 no. 6 p. 1723-1733en_GB
dc.identifier.issn0730-7268 (online)en_GB
dc.description.abstractBased on the results of a Horizon Scanning exercise sponsored by the Society of Environmental Toxicology and Chemistry that focused on advancing the adverse outcome pathway (AOP) framework, the development of guidance related to AOP network development was identified as a critical need. This not only included questions focusing directly on AOP networks, but also on related topics such as mixture toxicity assessment and the implementation of feedback loops within the AOP framework. A set of two articles has been developed to begin exploring these concepts. In the present article (part I), we consider the derivation of AOP networks in the context of how it differs from the development of individual AOPs. We then propose the use of filters and layers to tailor AOP networks to suit the needs of a given research question or application. We briefly introduce a number of analytical approaches that may be used to characterize the structure of AOP networks. These analytical concepts are further described in a dedicated, complementary article (part II). Finally, we present a number of case studies that illustrate concepts underlying the development, analysis, and application of AOP networks. The concepts described in the present article and in its companion article (which focuses on AOP network analytics) are intended to serve as a starting point for further development of the AOP network concept, and also to catalyze AOP network development and application by the different stakeholder communities.en_GB
dc.description.sponsorshipJRC.F.3-Chemicals Safety and Alternative Methodsen_GB
dc.titleAdverse outcome pathway networks I: Development and applicationsen_GB
dc.typeArticles in periodicals and booksen_GB
dc.identifier.doi10.1002/etc.4125 (online)en_GB
JRC Directorate:Health, Consumers and Reference Materials

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