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|Title:||Progress toward the Validation of Alternative Tests.|
|Authors:||BALLS Michael; FENTEM Julia helen|
|Citation:||Alternatives to Laboratory Animals (ATLA) vol. 25 p. 33-43|
|Type:||Contributions to Conferences|
|Abstract:||ECVAM's role in practical validation of replacement alternative methods for use in regulatory testing is reviewed, including an outline of the criteria which have been used in determining ECVAM's properties. Some of the difficulties which have arisen in validation studies are discussed, and solutions to these are proposed, with particular emphasis on ensuring that methods are sufficiently well developed to enter the validation process, and on the ECVAM prevalidation scheme for encouraging protocol optimisation and the prior assessment of interlaboratory transferability. Comments are made on problems encountered in selecting test materials backed by adequate in vivo data and in undertaking appropriate in vivo/in vitro comparisons. Finally, reference is made to ECVAM's activities related to dermal toxicity testing.|
|JRC Institute:||Joint Research Centre Historical Collection|
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