Title: Cytotoxicity of 213Bi- and 225Ac-Immunoconjugates
Authors: KASPERSEN F.m.BOS E.DOORNMALEN A.v.APOSTOLIDIS Christos
Citation: Nuclear Medicine Communications vol. 16 p. 468-476
Publication Year: 1996
JRC N°: JRC13471
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC13471
Type: Articles in Journals
Abstract: The paper describes in vitro cytotoxicity experiments with 213-Bi- and 225-Ac-immunoconjugates on the human epidermoid tumour cell line A431 using a blood group A-reactive murine IgG (2D11) as the specific antibody and MOPC 21 as the control antibody. With both radionuclides, specific cell-killing was achieved. The observed cytotoxicity of 213-Bi (T 1/2 = 47 min) indicates that this radionuclide is a useful alternative for the alpha-emitter 212-Bi in the treatment of blood-borne malignancies. 225-Ac-immuno-conjugates may be applicable for the treatment of solid tumours, since the daughter radionuclides of 225-Ca contribute to the cytotoxic efficacy by a field effect (i.e. toxicity in an area distal from antibody-binding site). The lack of an adequate chelator for 225-Ac is a major drawback.
JRC Institute:Institute for Transuranium Elements

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