Title: Progress Toward the Validation of Alternative Tests
Authors: BALLS MichaelFENTEM Julia helen
Citation: Alternatives to Laboratory Animals (ATLA) vol. 25 p. 33-34
Publication Year: 1997
JRC Publication N°: JRC14552
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC14552
Type: Articles in Journals
Abstract: ECVAM's role in the practical validation of replacement alternative methods for use in regulatory testing is reviewed, including an outline of the criteria which have been used in determining ECVAM's priorities. Some of the difficulties which have arisen in validation studies are discussed, and solutions to these are proposed, with particular emphasis on ensuring that methods are sufficiently well-developed to enter the validation process, and on the ECVAM prevalidation scheme for encouraging protocol optimisation and the prior assessment of interlaboratory transferability. Comments are made on problems encountered in selecting test materials backed by adequate in vivo data and in undertaking appropriate in vivo/in vitro comparisons.
JRC Institute:Joint Research Centre Historical Collection

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