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|Title:||Production of Ac-225 from Th-229 for Targeted Alpha Therapy|
|Authors:||APOSTOLIDIS CHRISTOS; MOLINET Roger; MORGENSTERN ALFRED|
|Citation:||ANALYTICAL CHEMISTRY vol. 77 no. 19 p. 6288-6291|
|Publisher:||AMER CHEMICAL SOC|
|Type:||Articles in periodicals and books|
|Abstract:||This work describes a method for the separation and purification of Ac-225 from a Th-229 source. The procedure is based on the combination of ion exchange and extraction chromatographic methods in nitric acid media and allows the preparation of carrier-free, clinical grade Ac-225 with an overall yield exceeding 95%. Quality control of the product is performed using radiometric (r, ç spectrometry) and mass spectrometric methods. The Ac- 225 product can be loaded on a radionuclide generator for the preparation of Bi-213 for preclinical and clinical studies of targeted r therapy of cancer and infectious diseases.|
|JRC Institute:||Nuclear Safety and Security|
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