Title: Tailoring Surface Properties of Biomedical Polymers by Implantation of Ar and He Ions
Authors: MANSO SILVAN MiguelVALSESIA ANDREALEJEUNE MichaelGILLILAND DOUGLASCECCONE GIACOMOROSSI FRANCOIS
Citation: ACTA MATERIALIA vol. 1 no. 4 p. 431-440
Publisher: ELSEVIER SCIENCE BV
Publication Year: 2005
JRC N°: JRC31767
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC31767
Type: Articles in Journals
Abstract: Ion implantation at 25 and 100 keV has been used as a tool for the modification of the surface properties of two biomedical polymers. The modulation induced by the different energy dispersion mechanisms of Ar and He have allowed satisfactory modifications for both the activation of the surfaces of chemically functional polycaprolactone (PCL) and the stabilization of anti-fouling poly(ethylene glycol) (PEG). In both cases the implantations have been performed at doses of 1014 cm−2 by taking into account the effect of different current densities, which are shown to distinctly influence the fragmentation-crosslinking of the target polymers. The resultant films were characterized by Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, time of flight secondary ion mass spectroscopy and atomic force microscopy. Both shifts in zeta potential versus pH curves and the alteration of the polar components of the surface free energy (contact angle measurements) were correlated with the composition analysis. The response of the modified surfaces towards biomolecular interaction is demonstrated by the induction of preferential adsorption on irradiated PCL and the inhibited adsorption onto implanted PEG regions for selected oligopeptides and proteins.
JRC Institute:Institute for Health and Consumer Protection

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