Title: Immobilization of RGD Peptides on Stable Plasma-Deposited Acrylic Acid Coatings for Biomedical Devices
Authors: LOPEZ L.c.GRISTINA R.CECCONE GIACOMOROSSI FRANCOISFAVIA P.D'AGOSTINO R.
Citation: SURFACE & COATINGS TECHNOLOGY vol. 200 no. 1-4 p. 1000-1004
Publisher: Elsevier B.V.
Publication Year: 2005
JRC N°: JRC31902
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC31902
Type: Articles in Journals
Abstract: Thin coatings were deposited in high fragmentation regimes from RF (13.56 MHz) glow discharges fed with acrylic acid vapours. These coatings were characterized by a low surface density of COOH groups and resulted homogeneous and very stable in water. PET coated samples were used for the covalent immobilization of RGD peptide via a bis amine spacer arm, using COOH surface functionalities as anchor groups. Substrates from the different steps of RGD immobilization were used for cell adhesion assays with 3T3 fibroblasts.
JRC Institute:Institute for Health and Consumer Protection

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