Title: Control of Cell Adhesion and Spreading by Spatial Microarranged PEO-like and pdAA Domains
Authors: SARDELLA E.GRISTINA R.CECCONE GIACOMOGILLILAND DOUGLASPAPADOPOULOU ANDRIROSSI FRANCOISSENESI G.s.DETOMASO L.FAVIA P.D'AGOSTINO R.
Citation: SURFACE & COATINGS TECHNOLOGY vol. 200 no. 1-4 p. 51-57
Publisher: Elsevier B.V.
Publication Year: 2005
JRC N°: JRC32021
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC32021
Type: Articles in Journals
Abstract: Microstructured surfaces are widely used in cell culture experiments to understand the fundamentals of cell-material interactions by a spatial control of cell adhesion and spreading. Recent studies have documented that both substrate chemistry and topography are tightly correlated to cell behaviours. For this reason a wide range of techniques have been explored for obtaining in a simple and cheap way reproducible patterned substrates. This paper describes how to produce micropatterned substrates by a spatial microarrangment of chemically different domains, produced by plasma deposition. Cell-repulsive zones, obtained by plasma deposited PolyethyleneOxide-like (PEO-like) coating, were alternated with cell-adhesive tracks, namely plasma deposited Acrylic Acid (pdAA) films. Time lapse experiments demonstrated that such patterns, suitable to exert chemical and topographical constraints for cell-adhesion, can also support migration of cells inside the produced pattern.
JRC Institute:Institute for Health and Consumer Protection

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