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|Title:||Control of Cell Adhesion and Spreading by Spatial Microarranged PEO-like and pdAA Domains|
|Authors:||SARDELLA E.; GRISTINA R.; CECCONE GIACOMO; GILLILAND DOUGLAS; PAPADOPOULOU ANDRI; ROSSI FRANCOIS; SENESI G.s.; DETOMASO L.; FAVIA P.; D'AGOSTINO R.|
|Citation:||SURFACE & COATINGS TECHNOLOGY vol. 200 no. 1-4 p. 51-57|
|Type:||Articles in Journals|
|Abstract:||Microstructured surfaces are widely used in cell culture experiments to understand the fundamentals of cell-material interactions by a spatial control of cell adhesion and spreading. Recent studies have documented that both substrate chemistry and topography are tightly correlated to cell behaviours. For this reason a wide range of techniques have been explored for obtaining in a simple and cheap way reproducible patterned substrates. This paper describes how to produce micropatterned substrates by a spatial microarrangment of chemically different domains, produced by plasma deposition. Cell-repulsive zones, obtained by plasma deposited PolyethyleneOxide-like (PEO-like) coating, were alternated with cell-adhesive tracks, namely plasma deposited Acrylic Acid (pdAA) films. Time lapse experiments demonstrated that such patterns, suitable to exert chemical and topographical constraints for cell-adhesion, can also support migration of cells inside the produced pattern.|
|JRC Institute:||Institute for Health and Consumer Protection|
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