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|Title:||Functional Micropatterned Surfaces by Combination of Plasma Polymerization and Lift-Off Processes|
|Authors:||BRETAGNOL FREDERIC; CERIOTTI LAURA; LEJEUNE Michael; PAPADOPOULOU ANDRI; HASIWA MARINA; GILLILAND DOUGLAS; CECCONE GIACOMO; COLPO Pascal; ROSSI FRANCOIS|
|Citation:||PLASMA PROCESSES AND POLYMERS vol. 3 no. 1 p. 30-38|
|Publisher:||WILEY-V C H VERLAG GMBH|
|Type:||Articles in Journals|
|Abstract:||In this study, microstructured surfaces are produced by a spatial arrangement of different functional domains by a combination of plasma polymerization and photolithography. Two different kinds of protein and cell adhesive patterns have been alternated with non-fouling areas. Non-fouling patterns are made of poly(ethylene oxide) (PEO)-like polymers obtained by pulsed plasma polymerization of diethylene glycol dimethyl ether, which leads to coatings with a high concentration of ethylene oxide groups (>70%). Fouling surfaces are composed of PEO coatings with a low concentration of ethylene oxide groups (40%) and films containing amino groups (from allylamine monomer) obtained by plasma polymerization. High pattern fidelity is demonstrated by ellispometry measurements, whereas XPS and ToF-SIMS analyses have been used to characterize the surfaces. Experiments with a model protein (bovine serum albumin) and cells (L929 mouse fibroblasts) on patterned surfaces show that proteins and cells only adhere on the patterns, whereas the background stays uncovered.|
|JRC Institute:||Institute for Health and Consumer Protection|
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