Title: Cyclotron Production of Ac-225 for Targeted Alpha Therapy
Authors: APOSTOLIDIS CHRISTOSMOLINET RogerMCGINLEY JOHNABBAS KAMELMOELLENBECK J.MORGENSTERN ALFRED
Citation: APPLIED RADIATION AND ISOTOPES vol. 62 p. 383-387
Publisher: ELSEVIER SCI LTD
Publication Year: 2005
JRC N°: JRC32186
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC32186
Type: Articles in Journals
Abstract: The feasibility of producing Ac-225 by proton irradiation of Ra-226 in a cyclotron through the reaction Ra-226(p,2n)Ac-225 has been experimentally demonstrated for the first time. Proton energies were varied from 8.8 to 24.8MeV and cross-sections were determined by radiochemical analysis of reaction yields. Maximum yields were reached at incident proton energies of 16.8 MeV. Radiochemical separation of Ac-225 from the irradiated target yielded a product suitable for targeted alpha therapy of cancer.
JRC Institute:Institute for Health and Consumer Protection

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