Title: Optimisation Study of Alpha Cyclotron Production of At-211/Po-211g for High-LET Metabolic Radiotherapy Purposes
Authors: GROPPI FBONARDI M LBIRATTARI CMENAPACE EABBAS KAMELHOLZWARTH UWEALFARANO ANNAMORZENTI SZONA CALFASSI Z B
Citation: APPLIED RADIATION AND ISOTOPES vol. 63 p. 621-631
Publisher: ELSEVIER SCI LTD
Publication Year: 2005
JRC Publication N°: JRC32238
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC32238
Type: Articles in Journals
Abstract: The production of no-carrier-added (NCA) a-emitter 211At: 211gPo radionuclides for high-LET targeted radiotherapy and immunoradiotherapy, through the 209Bi(a,2n) reaction, together with the required wet radiochemistry and radioanalytical quality controls carried out at LASA is described, through dedicated irradiation experiments at the MC-40 cyclotron of JRC-Ispra. The amount of both the g-emitter 210At and its long half-lived a-emitting daughter 210Po is optimised and minimised by appropriate choice of energy and energy loss of a particle beam. The measured excitation functions for production of the main radioisotopic impurity 210At- 210Po are compared with theoretical predictions from model calculations performed at ENEA.
JRC Institute:Institute for Health and Consumer Protection

Files in This Item:
There are no files associated with this item.


Items in repository are protected by copyright, with all rights reserved, unless otherwise indicated.