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|Title:||Long-Term Stability of Relationships between Reference Materials for Thromboplastins|
|Authors:||LINSINGER THOMAS; VAN DEN BESSELAAR A.m.h.; TRIPODI A.|
|Citation:||THROMBOSIS AND HAEMOSTASIS vol. 96 p. 210-214|
|Publisher:||F K SCHATTAUER VERLAG GMBH|
|Type:||Articles in Journals|
|Abstract:||Reference materials for thromboplastins are available from the World Health Organization (WHO) and the European Commission (EC). The long-term stability of the reference materials is an essential requirement and should be monitored. The relationship between two reference materials for rabbit thromboplastin, i.e. CRM149S (EC) and RBT/90 (WHO), has been monitored in the period 1996-2002. No significant trend with time was detected. In addition, the relatioship between CRM149S and the reference material for bovine thromboplastin (i.e. OBT/79) has been determined in 1994 and in 2005 in multicentre studies (n=11 and n=9, respectively). No significant changes were observed in the relationships between these reference materials when all results were included (5% significance level). When one center's outlying international sensitivity index (ISI) was excluded, a 4% difference in the mean ISI was significant at the 5% level.|
|JRC Institute:||Institute for Reference Materials and Measurements|
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