Title: Alpha Cyclotron Production Studies of the Aplhe Emitter At-211/Po-211g for High-LET Metabolic Radiotherapy
Authors: MORZENTI SBONARDI M LGROPPI FCANELLA LMENAPACE EALFASSI Z BABBAS KAMELHOLZWARTH UWE
Citation: Astroparticle, Particle and Space Physics, Detectors and Medical Physics Applications - Proceedings of the 9th Conference
Publisher: World Scientific
Publication Year: 2006
JRC Publication N°: JRC33859
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC33859
Type: Contributions to Conferences
Abstract: A series of high specific activity accelerator-produced radionuclides in no-carrier-added (NCA) form, for uses in metabolic radiotherapy and for PET, has been investigated and produced at JRC-Ispra Cyclotron Laboratory. In this study we present, in particular, the NCA 211At/211gPo (LET = 130 eV.nm-1, t1/2 = 7.214 h), produced by 209Bi(,2n) reaction, with internal spike of gamma emitter 210At (e.g. negligible amount of 210Po as radiotoxic long-lived impurity), for high-LET targeted radiotherapy and immunoradiotherapy. A selective radiochemical separation, based on liquid/liquid extraction, of At radionuclides from Bi target and Po impurities has been developed. High resolution gamma, X and alpha spectrometric techniques have been adopted for quality controls of different radiochemical fractions.
JRC Institute:Institute for Health and Consumer Protection

Files in This Item:
There are no files associated with this item.


Items in repository are protected by copyright, with all rights reserved, unless otherwise indicated.