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|Title:||Alpha Cyclotron Production Studies of the Aplhe Emitter At-211/Po-211g for High-LET Metabolic Radiotherapy|
|Authors:||MORZENTI S; BONARDI M L; GROPPI F; CANELLA L; MENAPACE E; ALFASSI Z B; ABBAS KAMEL; HOLZWARTH UWE|
|Citation:||Astroparticle, Particle and Space Physics, Detectors and Medical Physics Applications - Proceedings of the 9th Conference|
|Type:||Articles in periodicals and books|
|Abstract:||A series of high specific activity accelerator-produced radionuclides in no-carrier-added (NCA) form, for uses in metabolic radiotherapy and for PET, has been investigated and produced at JRC-Ispra Cyclotron Laboratory. In this study we present, in particular, the NCA 211At/211gPo (LET = 130 eV.nm-1, t1/2 = 7.214 h), produced by 209Bi(,2n) reaction, with internal spike of gamma emitter 210At (e.g. negligible amount of 210Po as radiotoxic long-lived impurity), for high-LET targeted radiotherapy and immunoradiotherapy. A selective radiochemical separation, based on liquid/liquid extraction, of At radionuclides from Bi target and Po impurities has been developed. High resolution gamma, X and alpha spectrometric techniques have been adopted for quality controls of different radiochemical fractions.|
|JRC Institute:||Institute for Health and Consumer Protection|
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