Title: The Assessment of Repeated Dose Toxicity In Vitro: a Proposed Approach. The Report and Recommendations of ECVAM Workshop 56
Authors: PRIETO PERAITA MARIA DEL PILARBAIRD Alan W.BLAAUBOER Bas J.CASTELL RIPOLL Jose VicenteCORVI RAFFAELLADEKANT WolfgangDIETL PaulGENNARI AlessandraGRIBALDO LAURAHARTUNG THOMASGRIFFIN Julian L.HEINDEL Jerry J.HOET PeterJENNINGS PaulMAROCCHIO LucianaNORABERG JensPAZOS PatriciaWESTMORELAND CarlWOLF ArminWRIGHT JanePFALLER Walter
Citation: ATLA-ALTERNATIVES TO LABORATORY ANIMALS vol. 34 no. 3 p. 315-341
Publisher: FRAME
Publication Year: 2006
JRC Publication N°: JRC34126
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC34126
Type: Articles in Journals
Abstract: This is the 56th report of a series of workshops organised by the European Centre for the Validation of Alternative Methods (ECVAM). The main goal of ECVAM, as defined in 1993 by its Scientific Advisory Committee, is to promote the scientific and regulatory acceptance of alternative methods which have scientific relevance and which reduce, refine or replace the use of laboratory animals. One of the first priorities set by ECVAM was the implementation of procedures that would enable it to become well informed about the stateof- the-art of non-animal test development and validation, and the potential for the possible incorporation of alternative tests into regulatory procedures. It was decided that this would be best achieved by the organisation of ECVAM workshops on specific topics, at which focused groups of invited experts would review the current status of non animal- based tests and their potential uses, and make recommendations about the best ways forward (1). The ECVAM workshop on repeated dose toxicity in vitro was held on 15–17 September 2004, at ECVAM in Ispra, Italy. The workshop was chaired by Walter Pfaller and Pilar Prieto, and was attended by pharmacologists and toxicologists from academia, industry and government, from different research backgrounds and with different ways of thinking. The main goal was to discuss and evaluate alternative approaches to in vivo repeated dose toxicity testing.
JRC Institute:Institute for Health and Consumer Protection

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