Title: Local Trageting of Malignant Gliomas by the Difussible Peptidic Vector DOTAGA-substance P
Authors: KNEIFEL S.CORDIER D.GOOD S.IONESCU M.GHAFFARI A.HOFER S.KRETSCHMAR M.TOLNAY M.APOSTOLIDIS CHRISTOSWASER BARNOLD M.MUELLER-BRAND J.MAECKE H.r.REUBI J.c.MERLO A.
Citation: CLINICAL CANCER RESEARCH vol. 12 p. 3843-3850
Publisher: AMER ASSOC CANCER RESEARCH
Publication Year: 2006
JRC Publication N°: JRC34219
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC34219
Type: Articles in Journals
Abstract: Purpose: Malignant glial brain tumors consistentlyo verexpress neurokinin type 1receptors. In classic seed-based brachytherapy, one to several rigid 125I seeds are inserted, mainlyf or the treatment of small low-grade gliomas. The complex geometryo f rapidly proliferating high-grade gliomas requires a diffusible system targeting tumor-associated surface structures to saturate the tumor, including its margins.
JRC Institute:Institute for Transuranium Elements

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