Title: Thiolated Polyethylene Oxide as Non-Fouling Element for Nano-Patterned Bio-Devices
Authors: VIEIRA LISBOA PATRICIAVALSESIA ANDREACOLPO PascalGILLILAND DOUGLASCECCONE GIACOMOPAPADOPOULOU ANDRIRAUSCHER HUBERTRENIERO FABIANOGUILLOU CLAUDEROSSI FRANCOIS
Citation: APPLIED SURFACE SCIENCE vol. 253 p. 4796-4804
Publisher: ELSEVIER SCIENCE BV
Publication Year: 2007
JRC N°: JRC34582
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC34582
Type: Articles in Journals
Abstract: This work describes the synthesis of a thiolated polyethylene oxide that self-assembles on gold to create a non-fouling surface. Thiolated polyethylene oxide was synthesized by reacting 16-mercaptohexadecanoic acid with polyethylene glycol mono methyl ether. The coverage of the thiolated polyethylene oxide on gold was studied by Cyclic Voltammetry, and the modified surfaces were characterized by X-ray photoelectron Spectroscopy and Ellipsometry. Protein resistance was assessed using Quartz Crystal Microbalance. Results showed a non-fouling character produced by the thiolated polyethylene oxide. The synthesized product was used as the passivation layer on nano-patterned surfaces consisting of arrayed nano-spots, fabricated by plasma based colloidal lithography. The specific adsorption of anti-bovine serum albumin in the mercaptohexadecanoic acid spots was verified by Atomic force Microscopy.
JRC Institute:Institute for Health and Consumer Protection

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