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|Title:||Thiolated Polyethylene Oxide as Non-Fouling Element for Nano-Patterned Bio-Devices|
|Authors:||VIEIRA LISBOA PATRICIA; VALSESIA ANDREA; COLPO Pascal; GILLILAND DOUGLAS; CECCONE GIACOMO; PAPADOPOULOU ANDRI; RAUSCHER HUBERT; RENIERO FABIANO; GUILLOU CLAUDE; ROSSI FRANCOIS|
|Citation:||APPLIED SURFACE SCIENCE vol. 253 p. 4796-4804|
|Publisher:||ELSEVIER SCIENCE BV|
|Type:||Articles in Journals|
|Abstract:||This work describes the synthesis of a thiolated polyethylene oxide that self-assembles on gold to create a non-fouling surface. Thiolated polyethylene oxide was synthesized by reacting 16-mercaptohexadecanoic acid with polyethylene glycol mono methyl ether. The coverage of the thiolated polyethylene oxide on gold was studied by Cyclic Voltammetry, and the modified surfaces were characterized by X-ray photoelectron Spectroscopy and Ellipsometry. Protein resistance was assessed using Quartz Crystal Microbalance. Results showed a non-fouling character produced by the thiolated polyethylene oxide. The synthesized product was used as the passivation layer on nano-patterned surfaces consisting of arrayed nano-spots, fabricated by plasma based colloidal lithography. The specific adsorption of anti-bovine serum albumin in the mercaptohexadecanoic acid spots was verified by Atomic force Microscopy.|
|JRC Institute:||Institute for Health and Consumer Protection|
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