Title: Towards the Certification of the Purity of Calibrator Reference Materials for Thyroid Hormones: a Chicken and Egg Dilemma
Authors: TOUSSAINT BRIGITTESCHIMMEL HEINZKLEIN CHRISTOPHWIERGOWSKI MarekEMONS HENDRIK
Citation: JOURNAL OF CHROMATOGRAPHY A vol. 1156 no. 1-2 p. 236-248
Publisher: ELSEVIER SCIENCE BV
Publication Year: 2007
JRC N°: JRC34795
ISSN: 0021-9673
URI: http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TG8-4MMFVRK-3&_user=4900406&_coverDate=07%2F13%2F2007&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000036252&_version=1&_urlVersion=0&_userid=4900406&md5=3b7f569c1841c9d0b78c185ed77a0f02
http://publications.jrc.ec.europa.eu/repository/handle/JRC34795
DOI: 10.1016/j.chroma.2006.11.095
Type: Articles in Journals
Abstract: The certification of the purity of CRMs intended for calibration, where no other certified material already exists for comparison raises principle questions on how to determine the purity of a "first" calibrant in the calibration hierarchy. We developed and certified two CRMs for their purity in thyroid hormones (thyroxine (thyroxine, T4) and 3,3',5-triiodothyronine (T3)) taking into consideration inorganic residues, residual solvents and organic impurities detectable by HPLC-UV and HPLC-MS. The approach we used aims to determine the purity of these two CRMs to the best of our knowledge and taking all scientific aspects properly into account for the estimation of an uncertainty related to the stated purity.
JRC Institute:Institute for Reference Materials and Measurements

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