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|Title:||Transcriptomics and Proteomics - Application to Ecotoxicology|
|Authors:||CALZOLAI Luigi; ANSORGE Wilhelm; CALABRESE Edward; DENSLOW Nancy; PART PETER; LETTIERI TERESA|
|Citation:||Comparative Biochemistry and Physiology D-Genomics & Proteomics vol. 2 no. 3 p. 245-249|
|Publisher:||ELSEVIER SCIENCE INC|
|Type:||Articles in periodicals and books|
|Abstract:||The Joint Research Center (JRC) of the European Commission hosted a workshop, DNA microarray and Proteomics. Application to Ecotoxicology;, in Ispra, Italy, on May 19-20th 2005. Researchers from Europe and the USA met to discuss how to integrate gene and protein expression analyses with bioinformatics tools in the field of ecotoxicology and how this new approach could be translated in improved risk assessment procedures. The measurements of gene and/or protein expression levels, upon exposure to a chemical or a stressor, can be used to develop robust molecular biomarkers that will allow the early detection of environmental stress, study long-term exposure and infer the mechanism of action. These molecular biomarkers should be linked to traditional end points of exposure such as adverse effects in growth and reproduction in single organisms and populations. At the low concentrations of chemicals found in real environments there could be “non standard” dose-response curves and this possibility should be taken into account in the experimental design and in the analyses of the data. The application of gene and protein expression profiling in ecotoxicology will have a significant impact on the ecotoxicology field in the near future and international collaborations will play an important role in accelerating the application of those techniques.|
|JRC Institute:||Institute for Environment and Sustainability|
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