Title: Biological Stress Response Terminology: Integrating the Concepts of Adaptive Response and Preconditioning Stress Within a Hormetic Dose-Response Framework
Authors: CALABRESE EdwardBACHMANN Kenneth A.BAILER A. JohnBOLGER P. MichaelBORAK JonathanCAI LuCEDERGREEN NinaCHERIAN M. GeorgeCHIUEH Chuang C.CLARKSON Thomas W.COOK Ralph R.DIAMOND David M.DOOLITTLE David J.DORATO Michael A.DUKE Stephen O.FEINENDEGEN LudwigGARDNER Donald E.HART Ronald W.HASTINGS Kenneth L.HAYES A. WallaceHOFFMANN George R.IVES John A.JAWOROWSKI ZbigniewJOHNSON Thomas E.JONAS Wayne B.KAMINSKI Norbert E.KELLER John G.KLAUNIG James E.KNUDSEN Thomas B.KOZUMBO Walter J.LETTIERI TERESALIU Shu-ZhengMAISSEU AndreMAYNARD Kenneth I.MASORO Edward J.MCCLELLAN Roger O.MEHENDALE Harihara M.MOTHERSILL CarmelNEWLIN David B.NIGG Herbert N.OEHME Frederick W.PHALEN Robert F.PHILBERT Martin A.RATTAN Suresh I.s.RIVIERE Jim E.RODRICKS JosephSAPOLSKY Robert M.SCOTT Bobby R.SEYMOUR ColinSINCLAIR David A.SMITH-SONNEBORN JoanSNOW Elizabeth T.SPEAR LindaSTEVENSON Donald E.THOMAS YoleneTUBIANA MauriceWILLIAMS Gary M.MATTSON Mark P.
Citation: TOXICOLOGY AND APPLIED PHARMACOLOGY vol. 222 no. 1 p. 122-128
Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE
Publication Year: 2007
JRC N°: JRC34982
ISSN: 0041-008X
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC34982
Type: Articles in Journals
Abstract: Many biological subdisciplines that regularly assess dose-response relationships have identified an evolutionarily conserved process in which a low dose of a stressful stimulus activates an adaptive response that increases the resistance of the cell or organism to a moderate to severe level of stress. Due to a lack of frequent interaction among scientists in these many areas, there has emerged a broad range of terms that describe such dose-response relationships. This situation has become problematic because the different terms describe a family of similar biological responses (e.g., adaptive response, preconditioning, hormesis), adversely affecting interdisciplinary communication, and possibly even obscuring generalizable features and central biological concepts. With support from scientists in a broad range of disciplines, this article offers a set of recommendations we believe can achieve greater conceptual harmony in dose- response terminology, as well as better understanding and communication across the broad spectrum of biological disciplines.
JRC Institute:Institute for Environment and Sustainability

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