Title: Validation of an Analytical Method for the Determination of Spiramycin Virginiamycin and Tylosin in Feedingstuffs by Thin Layer Chromatography and Bioautography
Authors: VINCENT URSULAGIZZI GiseleVON HOLST CHRISTOPHDE JONG JacobMICHARD Jacques
Citation: FOOD ADDITIVES AND CONTAMINANTS vol. 24 no. 4 p. 351-359
Publisher: TAYLOR & FRANCIS LTD
Publication Year: 2007
JRC Publication N°: JRC35445
ISSN: 0265-203X
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC35445
DOI: 10.1080/02652030601075470
Type: Articles in Journals
Abstract: An inter-laboratory comparison was carried out to assess the method performance characteristics of an analytical method based on thin layer chromatography (TLC) coupled to microbiological detection (bio-autography) for screening feed samples for the presence of spiramycin, tylosin and virginiamycin. The required detection limit was 1 mg kg-1 (expressed in microbiological activity). For tylosin and virginiamycin, acceptable values of the sensitivity were obtained on all concentrations including 1 mg kg-1. Therefore the method fulfils the criterion regarding the required sensitivity at the target detection limit for tylosin and virginiamycin, whereas for spiramycin the limit of detection was 2 mg/kg.
JRC Institute:Institute for Reference Materials and Measurements

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