Title: Incorporating In Vitro Alternative Methods for Developmental Neurotoxicity into International Hazard and Risk Assessment Strategies
Authors: COECKE SANDRAGOLDBERG AlanALLEN SandraBUZANSKA LEONORACALAMANDREI GemmaCROFTON KevinHARENG L.HARTUNG THOMASKNAUT HOLGERHONEGGER PaulJACOBS MIRIAMLEIN PamelaLI AbbyMUNDY WilliamOWEN DavidSCHNEIDER SteffenSILBERGELD EllenREUM TorstenTRNOVEC TomasMONNET-TSCHUDI FloriannePRICE ANNA
Citation: ENVIRONMENTAL HEALTH PERSPECTIVES vol. 115 no. 6 p. 924-931
Publisher: US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
Publication Year: 2007
JRC Publication N°: JRC35731
ISSN: 0091-6765
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC35731
Type: Articles in Journals
Abstract: This is the report of the first workshop on 'Incorporating In Vitro Alternative Methods for Developmental Neurotoxicity (DNT) Testing into International Hazard and Risk Assessment Strategies' held in Ispra, Italy on 19-21 April 2005. The workshop was hosted by the European Centre for the Validation of Alternative Methods (ECVAM) and jointly organized by ECVAM, the European Chemical Industry Council (CEFIC) and the Johns Hopkins University Center for Alternatives to Animal Testing (CAAT). The primary aim of the workshop was to identify and catalogue potential methods that could be used to assess how data from in vitro alternative methods could help to predict and identify DNT hazards. Working groups focused on two different aspects: (1) Details on the science available in the field of DNT, including discussions on the models available to capture the critical DNT mechanisms and processes, and (2) Policy and strategy aspects to assess the integration of alternative methods in a regulatory framework. This report summarises these discussions and details the recommendations and priorities for future work.
JRC Institute:Institute for Health and Consumer Protection

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