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|Title:||Structure/Function Relationships of Lipoteichoic Acids|
|Authors:||MORATH SIEGFRIED; VON AULOCK SONJA; HARTUNG THOMAS|
|Citation:||JOURNAL OF ENDOTOXIN RESEARCH vol. 11 no. 5 p. 348-356|
|Type:||Articles in Journals|
|Abstract:||The role of lipoteichoic acids (LTAs) from Gram-positive bacteria as immunostimulatory molecules was controversial for many years, as inadequate preparation methods as well as heterogeneous and endotoxin-contaminated commercial preparations led to conflicting results. An improved purification methodology for LTA now yields potent bioactive and chemically defined material, which is currently being characterized in various models. A synthetic analogue of Staphylococcus aureus LTA has proven the structure/function relationship. The key role of D-alanine esters for the immune response of LTA was confirmed by synthetic derivatives. The glycolipid anchor of LTA plays a central role analogous to the lipid A of LPS. Methodological aspects and criteria for quality assessment of LTA preparations are discussed.|
|JRC Institute:||Institute for Health and Consumer Protection|
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