Title: Structure/Function Relationships of Lipoteichoic Acids
Authors: MORATH SIEGFRIEDVON AULOCK SONJAHARTUNG THOMAS
Citation: JOURNAL OF ENDOTOXIN RESEARCH vol. 11 no. 5 p. 348-356
Publisher: MANEY PUBLISHING
Publication Year: 2005
JRC N°: JRC36059
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC36059
Type: Articles in Journals
Abstract: The role of lipoteichoic acids (LTAs) from Gram-positive bacteria as immunostimulatory molecules was controversial for many years, as inadequate preparation methods as well as heterogeneous and endotoxin-contaminated commercial preparations led to conflicting results. An improved purification methodology for LTA now yields potent bioactive and chemically defined material, which is currently being characterized in various models. A synthetic analogue of Staphylococcus aureus LTA has proven the structure/function relationship. The key role of D-alanine esters for the immune response of LTA was confirmed by synthetic derivatives. The glycolipid anchor of LTA plays a central role analogous to the lipid A of LPS. Methodological aspects and criteria for quality assessment of LTA preparations are discussed.
JRC Institute:Institute for Health and Consumer Protection

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