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|Title:||Identification of Borrelia Burgdorferi Ribosomal Protein L25 by the Phage Surface Display Method and Evaluation of the Protein's Value for Serodiagnosis|
|Authors:||MUELLER Markus; BUNK Sebastian; DITERICH Isabel; WEICHEL Michael; RAUTER Carolin; HASSLER Dieter; HERMANN Corinna; CRAMERI Reto; HARTUNG THOMAS|
|Citation:||JOURNAL OF CLINICAL MICROBIOLOGY vol. 44 no. 10 p. 3778-3780|
|Publisher:||AMER SOC MICROBIOLOGY|
|JRC Publication N°:||JRC36184|
|Type:||Articles in Journals|
|Abstract:||The phage surface display technique was used to identify Borrelia burgdorferi antigens. By affinity selection with immunoglobulin G from pooled sera of six Lyme borreliosis (LB) patients, the ribosomal protein L25 was identified. The diagnostic value of L25 was investigated by an enzyme-linked immunosorbent assay, using sera from 80 LB patients and 75 controls, and the use of the protein resulted in a specificity of 99% and a 23% sensitivity, which qualify L25 as a useful antigen when combined with others.|
|JRC Institute:||Institute for Health and Consumer Protection|
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