Title: Identification of Borrelia Burgdorferi Ribosomal Protein L25 by the Phage Surface Display Method and Evaluation of the Protein's Value for Serodiagnosis
Authors: MUELLER MarkusBUNK SebastianDITERICH IsabelWEICHEL MichaelRAUTER CarolinHASSLER DieterHERMANN CorinnaCRAMERI RetoHARTUNG THOMAS
Citation: JOURNAL OF CLINICAL MICROBIOLOGY vol. 44 no. 10 p. 3778-3780
Publisher: AMER SOC MICROBIOLOGY
Publication Year: 2006
JRC Publication N°: JRC36184
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC36184
Type: Articles in Journals
Abstract: The phage surface display technique was used to identify Borrelia burgdorferi antigens. By affinity selection with immunoglobulin G from pooled sera of six Lyme borreliosis (LB) patients, the ribosomal protein L25 was identified. The diagnostic value of L25 was investigated by an enzyme-linked immunosorbent assay, using sera from 80 LB patients and 75 controls, and the use of the protein resulted in a specificity of 99% and a 23% sensitivity, which qualify L25 as a useful antigen when combined with others.
JRC Institute:Institute for Health and Consumer Protection

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