Title: Micro-Spot, UV and Wetting Patterning Pathways for Applications of Biofunctional Aminosilane-Titanate Coatings
Authors: MANSO MiguelVALSESIA ANDREAHASIWA MARINARODRıGUEZ-NAVAS C.GILLILAND DOUGLASCECCONE GIACOMOGARCıA RUIZ G.p.ROSSI FRANCOIS
Citation: BIOMEDICAL MICRODEVICES vol. 9 no. 3 p. 287-294
Publisher: SPRINGER
Publication Year: 2007
JRC N°: JRC36255
ISSN: 1387-2176
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC36255
DOI: 10.1007/s10544-006-9027-1
Type: Articles in Journals
Abstract: The micropatterning of functional films for biomedical applications is a key part of the process leading to a precise application. In the present work we present three different methodologies to micro-design biofunctional aminosilane-titanate coatings. The chemical functionality of the surface immobilized amino groups was initially tested by surface characterization techniques. X-ray photoelectron spectroscopy was used to analyze the films before and after derivatization with Trifluoromethylbenzaldehyde while atomic force microscopy was used to study the adsorption kinetics onto these hybrid films. The three micropatterning pathways were selected for three different kinds of applications: (1) 300 µm spots were satisfactorily used for oligonucleotide immobilization, (2) Masked regions protected from UV irradiation were intensively coated by colloidal gold nanoparticles creating a drastic contrast with respect to the UV exposed areas, and (3) radial micro stripes, used afterwards for culturing cells, were created onto Si substrates by wetting from modified precursor solutions. The results are a clear indication of the versatility of hybrid aminosilanetitanate coatings for biomedical applications requiring micropatterned biofunctional surfaces.
JRC Institute:Institute for Health and Consumer Protection

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