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|Title:||Molecular Interaction between LTAs and L. delbrueckii Phages Depends on D4 Alanyl and alfa-Glucose Substitution of Poly(glycerophosphate) Backbones|
|Authors:||RÄISÄNEN Liisa; DRAING C.; PFITZENMAIER Markus; SCHUBERT Karin; JAAKONSAARI Tiina; VON AULOCK SONJA; HARTUNG THOMAS; ALATOSSAVA Tapani|
|Citation:||JOURNAL OF BACTERIOLOGY vol. 189 no. 11 p. 4135-4140|
|Publisher:||AMER SOC MICROBIOLOGY|
|JRC Publication N°:||JRC38179|
|Type:||Articles in Journals|
|Abstract:||Lipoteichoic acids (LTAs) have been shown to act as bacterial counterparts to the receptor binding proteins of LL-H, LL-H host range mutant LL-H-a21 and JCL1032. Here we have used HIC-purified LTAs from different phage resistant and sensitive strains of L. delbrueckii subsp. lactis. NMR analyses revealed variation in the degree of α-glucosyl and D-alanyl substitution of the 1,3-linked poly(glycerophosphate) LTAs between the phage sensitive and the phage resistant strains. Inactivation of phages was less effective if there was a high level of D-alanine residues in the LTA backbones. Prior incubation of the LTAs with α-glucose-specific lectin inhibited the LL-H phage inactivation. The overall level of decoration or the specific spatial combination of α-glucosyl substituted, D-alanyl substituted and nonsubstituted glycerol residues may also affect phage adsorption.|
|JRC Institute:||Institute for Health and Consumer Protection|
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