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|Title:||Physiologically based Kinetic Modelling (PBK Modelling): Meeting the 3Rs Agenda - The Report and Recommendations of ECVAM Workshop 63|
|Authors:||BOUVIER D'YVOIRE MICHEL; PRIETO PERAITA MARIA DEL PILAR; BLAAUBOER Bas J.; BOIS Frederic Yves; BOOBIS Alan; BROCHOT Céline; COECKE SANDRA; FREIDIG Andreas; GUNDERT-REMY Ursula; HARTUNG THOMAS; JACOBS MIRIAM; LAVÉ Thierry; LEAHY David E.; LENNERNÄS Hans; LOIZOU George D.; MEEK Bette; PEASE Camilla; ROWLAND Malcolm; SPENDIFF Martin; YANG Jiansong; ZEILMAKER Marco|
|Citation:||ATLA-ALTERNATIVES TO LABORATORY ANIMALS vol. 35 no. 6 p. 661-671|
|Type:||Articles in Journals|
|Abstract:||This is the 63rd report of a series of workshops organised by the European Centre for the Validation of Alternative Methods (ECVAM), within the Institute for Health and Consumer Protection (IHCP). The workshop, entitled ¿Physiologically based Kinetic Modelling (PBK): Meeting the 3Rs Agenda¿, was held at ECVAM (Ispra, Italy) on October 10-12, 2005. Participants included international experts in PBK modelling and in the risk assessment of chemical products, from academia, regulatory or risk assessment advisory bodies, and industry.The objectives of the workshop were: 1) to better define the potential role of PBK modelling, as a set of techniques capable of contributing to the reduction, refinement and replacement of the use laboratory animals in the risk assessment process of potentially toxic chemicals; 2) to identify the needs for technical improvements in PBK modelling and its applications; 3) to increase the understanding and acceptance of the capabilities and limitations of PBK modelling techniques in toxicological risk assessment by regulatory authorities. This consensus report describes the strategy proposed by the participants to meet these objectives. It is also intended to provide the non-expert reader with an overview of the field in relation to the 3Rs and with some key references.|
|JRC Institute:||Institute for Health and Consumer Protection|
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