Title: Physiologically based Kinetic Modelling (PBK Modelling): Meeting the 3Rs Agenda - The Report and Recommendations of ECVAM Workshop 63
Authors: BOUVIER D'YVOIRE MICHELPRIETO PERAITA MARIA DEL PILARBLAAUBOER Bas J.BOIS Frederic YvesBOOBIS AlanBROCHOT CélineCOECKE SANDRAFREIDIG AndreasGUNDERT-REMY UrsulaHARTUNG THOMASJACOBS MIRIAMLAVÉ ThierryLEAHY David E.LENNERNÄS HansLOIZOU George D.MEEK BettePEASE CamillaROWLAND MalcolmSPENDIFF MartinYANG JiansongZEILMAKER Marco
Citation: ATLA-ALTERNATIVES TO LABORATORY ANIMALS vol. 35 no. 6 p. 661-671
Publisher: FRAME
Publication Year: 2007
JRC Publication N°: JRC40122
ISSN: 0261-1929
URI: http://www.frame.org.uk/
http://publications.jrc.ec.europa.eu/repository/handle/JRC40122
Type: Articles in Journals
Abstract: This is the 63rd report of a series of workshops organised by the European Centre for the Validation of Alternative Methods (ECVAM), within the Institute for Health and Consumer Protection (IHCP). The workshop, entitled ¿Physiologically based Kinetic Modelling (PBK): Meeting the 3Rs Agenda¿, was held at ECVAM (Ispra, Italy) on October 10-12, 2005. Participants included international experts in PBK modelling and in the risk assessment of chemical products, from academia, regulatory or risk assessment advisory bodies, and industry.The objectives of the workshop were: 1) to better define the potential role of PBK modelling, as a set of techniques capable of contributing to the reduction, refinement and replacement of the use laboratory animals in the risk assessment process of potentially toxic chemicals; 2) to identify the needs for technical improvements in PBK modelling and its applications; 3) to increase the understanding and acceptance of the capabilities and limitations of PBK modelling techniques in toxicological risk assessment by regulatory authorities. This consensus report describes the strategy proposed by the participants to meet these objectives. It is also intended to provide the non-expert reader with an overview of the field in relation to the 3Rs and with some key references.
JRC Institute:Institute for Health and Consumer Protection

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