Title: Gemcitabine Radiosensitizes Multiple Myeloma Cells to Low LET, but not High LET, Irradiation
Authors: SUPIOT S.THILLAYS F.RIO E.GOUARD S.MORGENSTERN ALFREDBRUCHERTSEIFER FRANKMAHE M. A.CHATAL J. F.DAVODEAU F.CHEREL M.
Citation: RADIOTHERAPY AND ONCOLOGY vol. 83 p. 97-101
Publisher: ELSEVIER IRELAND LTD
Publication Year: 2007
JRC Publication N°: JRC41945
ISSN: 0167-8140
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC41945
DOI: 10.1016/j.radonc.2007.02.005
Type: Articles in Journals
Abstract: The radiosensitizing properties of gemcitabine in relation to low Linear Energy Transfer (LET) particles (Cobalt 60) and high-LET particles (alpha-RIT 213Bi-radiolabeled CHX-DTPA-B-B4) were analyzed. Three multiple myeloma cell lines (LP1, RPMI 8226, U266) were irradiated with or without 10 nM gemcitabine 24 h prior to radiation. Gemcitabine led to radiosensitization of LP1 and U266 cells with low-LET (Radiation Enhancement Ratio: 1.55 and 1.49, respectively) but did not radiosensitize any cell line when combined with high-LET.
JRC Institute:Institute for Transuranium Elements

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