Title: Experimental Study of the Influence of Ar/H2 Microwave Discharges on Lipid A
Authors: KYLIAN ONDREJHASIWA MARINAGILLILAND DOUGLASROSSI FRANCOIS
Citation: Plasma Processes and Polymers vol. 5 no. 1 p. 26-32
Publisher: WILEY-V C H VERLAG GMBH
Publication Year: 2008
JRC N°: JRC42238
ISSN: 1612-8850
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC42238
DOI: 10.1002/ppap.200700093
Type: Articles in Journals
Abstract: This paper discusses the influence of microwave discharge plasmas on Lipid A, one of the most problematic compounds from the point of view of conventional decontamination methods. The effect of microwave discharges produced in different Ar/H2 mixtures on Lipid A films has been studied by means of both biological tests and materials characterisation methods (FT-IR and ToF-SIMS spectroscopy) in order to identify the main mechanisms leading to the suppression of their pyrogenicity. From the results obtained, it is concluded that most probably chemical modifications, namely the removal of long carboxylic acid chains and mineralisation of the organo-phosphate group, are responsible for Lipid A depyrogenation.
JRC Institute:Institute for Health and Consumer Protection

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