Title: Use of Nanopatterned Surfaces To Enhance Immunoreaction Efficiency
Authors: VALSESIA ANDREACOLPO PASCALMANNELLI ILARIAMORNET StephaneBRETAGNOL FREDERICCECCONE GIACOMOROSSI FRANCOIS
Citation: ANALYTICAL CHEMISTRY vol. 80 no. 5 p. 1418-1424
Publisher: AMER CHEMICAL SOC
Publication Year: 2008
JRC N°: JRC43109
ISSN: 0003-2700
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC43109
DOI: 10.1021/ac701762k
Type: Articles in Journals
Abstract: In this work, we compare the immunoreaction efficiency between uniformly functionalized surface and chemically nanopatterned surfaces when applied as platforms for antigen/antibody interactions with and without the use of protein A as orienting protein. On the anopatterned platform, the immunoreaction efficiency is higher than all the other cases with no protein A pretreatment of the surface, providing evidence of the capability of the adhesive/antiadhesive nanopatterned surface to immobilize the molecules in a reactive state, increasing their possibility to form complexes.
JRC Institute:Institute for Health and Consumer Protection

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