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|Title:||Stem-cell Culture on Patterned Bio-Functional Surfaces|
|Authors:||RUIZ ANA MARIA; BUZANSKA LEONORA; CERIOTTI LAURA; BRETAGNOL FREDERIC; COECKE SANDRA; COLPO PASCAL; ROSSI FRANCOIS|
|Citation:||JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION vol. 19 no. 12 p. 1649-1657|
|Type:||Articles in Journals|
|Abstract:||Bio-functional surfaces have been created by printing proteins on antifouling surfaces in a customised geometry. Human Umbilical Cord Neural Stem Cells incubated on the samples readily attach to the protein defined domains, where they have been monitored during 21 days of culture. The stability of the pattern varies with the density of cells anchored to the microstamped proteins. Highly packed cell patterned domains favoured non-differentiated mode, while low density areas allowed the spreading out of the cells and differentiation. Tailoring the geometry (pattern size and distances) enables improving the monitoring of the stem cells developmental processes. The biocompatible surfaces can serve as a model to study processes accompanying stem cell neural lineage commitment.|
|JRC Institute:||Institute for Health and Consumer Protection|
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