Title: An Evaluation of Performance Standards and Non-Radioactive Endpoints for the Local Lymph Node Assay
Authors: BASKETTER DavidCOCKSHOTT AmandaCORSINI EmanuelaGERBERICK FrankIDEHARA KenjiKIMBER IanVAN LOVEREN HenkMATHESON JohannaMEHLING AnnetteOMORI TakashiROVIDA MARIASOZU TakashiTAKEYOSHI MasahiroCASATI SILVIA
Citation: ATLA-ALTERNATIVES TO LABORATORY ANIMALS vol. 36 p. 243-257
Publisher: FRAME
Publication Year: 2008
JRC Publication N°: JRC43624
ISSN: 0261-1929
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC43624
Type: Articles in Journals
Abstract: A Workshop on Alternative Endpoints for the Local Lymph Node Assay was held at ECVAM (Ispra, Italy) on 25-27 September 2007, under the chairmanship of David Basketter. The workshop was attended by experts from academia, industry, national organisation, and national and international validation authorities. At present, the local lymph node assay (LLNA) uses radiolabelled thymidine as part of the standard protocol. The aim of the workshop was to review the state of the art of methods using non-radioactive endpoints for the LLNA and to consider Performance Standards for their eventual assessment. At the end of the report are listed the recommendations that should be considered for progressing towards validation of relevant and reliable methods
JRC Institute:Institute for Health and Consumer Protection

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