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|Title:||ECVAM Key Area Ecotoxicology: Summary of Activities and Future Perspectives|
|Authors:||PART PETER; HALDER MARIA|
|Citation:||COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOG vol. 146 no. 4 Supplement 1 p. S71|
|Publisher:||ELSEVIER SCIENCE INC|
|Type:||Articles in periodicals and books|
|Abstract:||The European Centre for Validation of Alternative Methods (ECVAM) is part of the European Commission and is responsible for the development and validation of methods which would reduce, refine and replace (3Rs) the use of animals for the safety testing of chemicals and other products. ECVAM¿s activities in ecotoxicology started 2001 with a workshop on ¿The use of fish cells in ecotoxicology¿ (Castaño et al. (2003). ATLA 31, 317¿351) followed by the establishment of a ECVAM Taskforce Ecotoxicology composed by Commission and Non-commission experts giving scientific advice on 3Rs methods and testing strategies. The approaches focus on acute aquatic toxicity and bioaccumulation being the two endpoints in the regulatory framework (e.g. REACH, agrochemicals, pharmaceuticals), which use large numbers of fish. Thus, the threshold approach, a reduction strategy for acute aquatic toxicity testing recently approved by the ECVAM Scientific Advisory Committee (ESAC) has the potential to reduce the number of fish by 50%. Its implementation is discussed at European Union and OECD level. In partnership with regulatory bodies, industry and academia ECVAM is involved in various projects aiming at the complete replacement of the acute fish test using a testing strategy based on fish cells and fish embryos. ECVAM collaborates with ILSI HESI on reducing the number of fish in bioaccumulation testing and will launch a study evaluating the use of in vitro methods for this purpose. More information on ECVAM: Marlies.Halder@jrc.it.|
|JRC Institute:||Institute for Environment and Sustainability|
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