Title: Transcriptomics and Proteomics - Application to Ecotoxicology
Authors: CALZOLAI LANSORGE WCALABRESE EDENSLOW NPART PETERLETTIERI TERESA
Citation: Comparative Biochemistry and Physiology D-Genomics & Proteomics vol. 2 no. 3 p. 245-249
Publisher: ELSEVIER SCIENCE INC
Publication Year: 2007
JRC Publication N°: JRC43648
ISSN: 1744-117X
URI: http://dx.doi.org/10.1016/j.cbd.2007.04.007
http://publications.jrc.ec.europa.eu/repository/handle/JRC43648
DOI: 10.1016/j.cbd.2007.04.007
Type: Articles in Journals
Abstract: The Joint Research Center (JRC) of the European Commission hosted a workshop, DNA microarray and Proteomics. Application to Ecotoxicology;, in Ispra, Italy, on May 19-20th 2005. Researchers from Europe and the USA met to discuss how to integrate gene and protein expression analyses with bioinformatics tools in the field of ecotoxicology and how this new approach could be translated in improved risk assessment procedures. The measurements of gene and/or protein expression levels, upon exposure to a chemical or a stressor, can be used to develop robust molecular biomarkers that will allow the early detection of environmental stress, study long-term exposure and infer the mechanism of action. These molecular biomarkers should be linked to traditional end points of exposure such as adverse effects in growth and reproduction in single organisms and populations. At the low concentrations of chemicals found in real environments there could be ¿non standard¿ dose-response curves and this possibility should be taken into account in the experimental design and in the analyses of the data. The application of gene and protein expression profiling in ecotoxicology will have a significant impact on the ecotoxicology field in the near future and international collaborations will play an important role in accelerating the application of those techniques.
JRC Institute:Institute for Environment and Sustainability

Files in This Item:
There are no files associated with this item.


Items in repository are protected by copyright, with all rights reserved, unless otherwise indicated.