Title: Neural In Vitro Culture on Microelectrode Arrays (MEAs) as a Biosensor for Toxins and Neurotoxins Detection
Authors: SOBANSKI TOMASZHOGBERG HELENAWHELAN MAURICEPRICE ANNA
Citation: Elektronika no. 6 p. 35-37
Publisher: Sigma-Not
Publication Year: 2008
JRC N°: JRC44283
ISSN: 0033-2089
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC44283
Type: Articles in Journals
Abstract: Recently in vitro systems are widely used for assessment of toxicological and pharmaceutical properties of chemicals. The latest developments in the field on in vitro toxicology and pharmacology demands a new assays focused on endpoints strictly related to the tissue specific functions. One of such methods, based on electrophysiological measurements of spontaneous activity from planar neural structure using microelectrode arrays (MEA) will be presented in this paper. This type of biosensor is very sensitive to the neurotoxins, relatively stable and reproducible and suitable for long term monitoring (up to 9 months).
JRC Institute:Institute for Health and Consumer Protection

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