Title: Use of Recovery and Bias Information in Analytical Chemistry and Estimation of its Uncertainty Contribution
Citation: TRAC-TRENDS IN ANALYTICAL CHEMISTRY vol. 27 no. 10 p. 916-923
Publication Year: 2008
JRC N°: JRC44567
ISSN: 0165-9936
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC44567
DOI: 10.1016/j.trac.2008.08.013
Type: Articles in periodicals and books
Abstract: Determination of method trueness, or, in its negative term, method bias is generally recognised as intrinsic part of method validation. However, different viewpoints still exists on how to estimate a potential bias, whether to correct for a potential bias and how to accomodate the bias and its uncertainty in the uncertainty budget for a particular measurement. Base don the scientified literature as well as guidance documents from international bodies (ISO, IUPAC, Eurachem, ICH, APLAC etc.) this review concludes that results should generally be corrected from know bias/incomplete recovery. The uncertainty of the bias forms an intrinsic part of the measurement uncertainty, even when no significant bias was observed.
JRC Directorate:Health, Consumers and Reference Materials

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