Title: The CarcinoGENOMICS Project: Critical Selection of Model Compounds for the Development of Omics-based in vitro Carcinogenicity Screening Assays
Authors: VINKEN MathieuDOKTOROVA TatyanaELLINGER-ZIEGELBAUER HeidrunAHR Hans-JuergenLOCK EdwardCARMICHAEL PaulROGGEN ErwinVAN DELFT JoostKLEINJANS JosCASTELL JoseBORT RoqueDONATO TeresaRYAN MichaelCORVI RaffaellaKEUN HectorEBBELS TimothyATHERSUCH TobySANSONE Susanna-AssuntaROCCA-SERRA PhilippeSTIERUM RobJENNINGS PaulPFALLER WalterGMUENDER HansVANHAECKE TamaraROGIERS Vera
Citation: MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH vol. 659 p. 202-210
Publisher: ELSEVIER SCIENCE BV
Publication Year: 2008
JRC Publication N°: JRC46470
ISSN: 1383-5742
URI: http://dx.doi.org/10.1016/j.mrrev.2008.04.006
http://publications.jrc.ec.europa.eu/repository/handle/JRC46470
DOI: 10.1016/j.mrrev.2008.04.006
Type: Articles in Journals
Abstract: Recent changes in the European legislation of chemical-related substances have forced the scientific community to speed up the search for alternative methods that could partly or fully replace animal experimentation. The sixth Framework Program project carcinoGENOMICS was specifically raised to develop omics-based in vitro screens for testing the carcinogenic potential of chemical compounds in a pan-European context. This paper provides an in-depth analysis of the complexity of choosing suitable reference compounds used for creating and fine-tuning the in vitro carcinogenicity assays. First, a number of solid criteria for the selection of the model compounds are defined. Secondly, the strategy followed, including resources consulted, is described and the selected compounds are briefly illustrated. Finally, limitations and problems encountered during the selection procedure are discussed. Since selecting an appropriate set of chemicals is a frequent impediment in the early stages of similar research projects, the information provided in this paper might be extremely valuable.
JRC Institute:Institute for Health and Consumer Protection

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