Title: A Set of Case Studies to Illustrate the Applicability of DART (Decision Analysis by Ranking Techniques) in the Ranking of Chemicals
Authors: WORTH AndrewPAVAN Manuela
Publisher: OPOCE
Publication Year: 2008
JRC N°: JRC47007
ISSN: 1018-5593
Other Identifiers: EUR 23481 EN
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC47007
Type: EUR - Scientific and Technical Research Reports
Abstract: This report provides the results of exploratory research carried out during 2007 and 2008 within the JRC¿s Institute for Health & Consumer Protection. The research focused on the problem of ranking chemicals according to their environmental and toxicological concern, and aimed to develop a better understanding of how to apply such approaches in the implementation of chemicals legislation, such as REACH and the Water Framework Directive. A number of limitations were identified in existing approaches for the prioritisation of chemicals. For example, the traditional EU tool, EURAM, was difficult to apply in a consistent way due to the fact that many of the data inputs needed were often missing, which meant that high priority was often given to data-poor chemicals, rather than chemicals that were inherently hazardous or likely to cause a significant risk. This project aimed to address limitations such as this by encoding novel ranking methods into a new user-friendly software tool, and by investigating the applicability of the tool in a number of case studies. The tool developed in this project, called DART (Decision Analysis by Ranking Techniques), is made freely downloadable from the JRC website. The applicability of DART tool is illustrated through a set of case studies. The first case study aims to summarise and illustrate different ways in which chemometric ranking methods could be used to supplement the use of QSAR methods in the development of chemical categories. The second case study illustrates how ranking methods could be used to supplement the use of QSAR methods in the context of toxicological assessments of potential persistent, bioaccumulative and toxic (PBT) substances. Finally, the third case study, aims to investigate the compatibility of established and novel ranking approaches with the risk assessment paradigm, in which hazard and exposure assessments are integrated into a characterisation of risk. These case studies illustrate some potential applications of ranking techniques in the regulatory assessment of chemicals.
JRC Institute:Institute for Health and Consumer Protection

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