Title: Pharmacogenetics in Europe: Barriers and Opportunities
Authors: GURWITZ DavidZIKA EleniHOPKINS Michael MGAISSER SibylleIBARRETA RUIZ Dolores
Citation: PUBLIC HEALTH GENOMICS vol. 12 no. 3 p. 134-141
Publisher: KARGER
Publication Year: 2009
JRC N°: JRC48083
ISSN: 1662-4246
URI: http://dx.doi.org/10.1159%2F000189625
http://publications.jrc.ec.europa.eu/repository/handle/JRC48083
DOI: 10.1159/000189625
Type: Articles in Journals
Abstract: This paper reviews the current situation in the field of pharmacogenetics/ pharmacogenomics (PGx) in Europe. High expectations surrounding the clinical application of PGx remain largely unmet, as only a limited number of such applications have actually reached the market and clinical practice. Thus, the potential impact of PGx-based diagnostics on healthcare and its socio-economic implications are still unclear. With the aim of shedding some light on these uncertainties, the JRC-IPTS has conducted a review of the ¿state-of-the-art¿ and a further analysis on the use of pharmacogenetics diagnostics for preventing toxic drug reactions and improving drug efficacy in Europe. The paper presents highlights from the JRC-IPTS studies and discusses possibilities for improving translation of PGx research in Europe by comparing some experiences in the USA. We also illustrate the related barriers for the clinical uptake of PGx in Europe with specific case-studies. Most of the barriers identified extend beyond the European context. This reflects the global problems of scarcity of data demonstrating proven clinical validity or utility, and favourable cost-effectiveness studies to support the clinical application of PGx diagnostic tests in the clinical setting. Another key barrier is the lack of incentives for the private sector to invest in the development and licensing of PGx diagnostic tests for improving the safety and efficacy of out-of-patent drugs. It therefore seems that one key aspect where policy can affect the clinical uptake of PGx is via sustaining large-scale industry-academia collaborations for developing and proving the utility of PGx diagnostics.
JRC Institute:Institute for Prospective Technological Studies

Files in This Item:
There are no files associated with this item.


Items in repository are protected by copyright, with all rights reserved, unless otherwise indicated.