Title: Cross-sections of the Reaction 232Th(p,3n)230Pa for Production of 230U for Targeted Alpha Therapy
Authors: MORGENSTERN AlfredAPOSTOLIDIS ChristosBRUCHERTSEIFER FrankCAPOTE R.GOUDER ThomasSIMONELLI FedericaSIN M.ABBAS Kamel
Citation: APPLIED RADIATION AND ISOTOPES vol. 66 p. 1275-1280
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Publication Year: 2008
JRC N°: JRC48526
ISSN: 0969-8043
URI: http://www.elsevier.com/locate/apradiso
http://publications.jrc.ec.europa.eu/repository/handle/JRC48526
DOI: 10.1016/j.apradiso.2008.02.066
Type: Articles in Journals
Abstract: 230U/226Th is a promising novel alpha-emitter system for application in targeted alpha therapy of cancer. The therapeutic nuclides can be produced by proton irradiation of natural 232Th according to the reaction 232Th(p,3n)230Pa, followed by subsequent beta decay of 230Pa to 230U. In this study, the experimental excitation function for the 232Th(p,3n)230Pa reaction up to 34MeV proton energy has been measured using the stacked-foil technique. The proton energies in the various foils were calculated with the SRIM 2003 code and gammaray spectrometry was used to measure the activities of the various radioisotopes produced. The measured cross-sections are in good agreement with selected literature values and with model calculations using the EMPIRE II code. The reaction 232Th(p,3n)230Pa allows the production of carrier-free 230U in clinically relevant levels.
JRC Institute:Institute for Transuranium Elements

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