Title: An in-vivo Comparison Study Between Standard and PET-based Approach to assess the Therapeutic Dose in Neutron Capture Therapies
Authors: CERULLO NicolaAIHARA TeruhitoHIRATSUKA JunichiKUMADA HiroakiLOMONACO GuglielmoCARIA SaraMUZI LanfrancoMOSS RaymondSAINATO AldoSORACE OresteBUFALINO Domenico
Other Contributors: DAQUINO Giuseppe Giovanni
Citation: 2008 IEEE Nuclear Science Symposium - Medical Imaging Conference Record p. 1-7
Publisher: IEEE operations Center
Publication Year: 2008
JRC N°: JRC48613
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC48613
Type: Articles in periodicals and books
Abstract: Previous studies [1,2] dedicated to the evaluation of the best approach for a treatment plan more consistent with the clinical findings opened a vexata quaestio, which is still an open issue as demonstrated by the fact that BNCT (Boron Neutron Capture Therapy) plans are only partially based on the pre-evaluation of the macroscopic boron distribution. For example, the evaluation of the T/N ratio through pre-irradiation PET scanning is undoubtedly a major improvement [3]. The present article shows that the Treatment Planning System (TPS) response is evidently different if it is applied with two approaches: on one hand, the definition of the target and other regions takes into consideration the tumour morphology obtained through CT scanning (standard). On the other hand, the target and other regions definition is based on the evaluation of the PET scanning of the same patient (PET-based). In particular, the case study is a 74 years old woman, affected by parotid progressive cancer. The PET scanning permitted to evaluate a T/N ratio equal to 5. The same patient has been CT scanned for the morphology reconstruction in the TPS. BDTPS (Boron Distribution) is a system designed, implemented and in-phantom tested at JRC-IE in collaboration to University of Pisa. It is possible to use this TPS in both approaches. In particular, PET data are integrated directly by the system in the post-processing evaluation of the 10B dose. The other doses (gamma, nitrogen and hydrogen) mainly present in BNCT are also calculated. The comparison between the two approaches gives a clear indication that the PET-based TPS offers more information in the peripheral area of the tumour, where the standard approach overestimates the boron dose. Consequently, the treatment plan calculates an irradiation time, insufficient to deliver a proper therapeutic dose in the area surrounding the main tumour core. The follow-up confirms the PET-based TPS findings. Additionally, the PET scanning helped to evaluate properly the T/N ratio, especially in zones where this ratio is too close to the unity. In this case, significant collateral damage occurs limiting the efficacy of BNCT. BDTPS can be applied to other capture therapies, such as GdNCT. Therefore, a PET-based treatment planning is a key for the most effective NCT. [1] G.G. Daquino, PET-based approach to treatment planning systems: an improvement toward successful Boron Neutron Capture Therapy (BNCT), 2003, ISBN 92-894-5507-1 [2] G.W. Kabalka, T.L. Nichols, G.T. Smith, L.F. Miller, M.K. Khan, P.M. Busse, The use of positron emission tomography to develop boron neutron capture therapy treatment plans for metastatic malignant melanoma, J. of Neuro-Oncology, 2003; 62:187-195 [3] K. Nagata, Y. Sakurai, M. Suzuki, Y. Kinashi, S. Masunaga, N. Morita, T. Aihara, J. Hiratsuka, Y. Imahori, A., Maruhashi, K. Ono, Estimation of intratumour boron concentration of boron neutron capture therapy for head and neck tumours using 18FBPA-PET image, Advances in Neutron Capture Therapy 2006, ISBN 4-9903242-0-X
JRC Directorate:Energy, Transport and Climate

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