Title: Improving Pharmacovigilance in Europe: TPMT Genotyping and Phenotyping in the UK and Spain
Authors: GURWITZ DavidRODRÍGUEZ-ANTONA CristinaPAYNE KatherineNEWMAN WilliamGISBERT Javier P.GUTIÉRREZ DE MESA EmmaIBARRETA RUIZ Dolores
Citation: EUROPEAN JOURNAL OF HUMAN GENETICS vol. 17 p. 991 - 998
Publisher: NATURE PUBLISHING GROUP
Publication Year: 2009
JRC Publication N°: JRC49763
ISSN: 1018-4813
URI: http://www.nature.com/ejhg
http://publications.jrc.ec.europa.eu/repository/handle/JRC49763
Type: Articles in Journals
Abstract: Thiopurine S-methyltransferase (TPMT) is the rate limiting step in the conversion of thiopurine drugs including azathioprine (AZA) to inactive metabolites. Heritable deficiency of TPMT activity increases risk for adverse events, most notably, myelosuppression leading to leucopenia and neutropenic sepsis. The reported European Commission study was undertaken to identify current evidence for the clinical utility of testing for TPMT status and extent of uptake, by either genotyping or phenotyping, in the clinical setting. Data presented here for the UK and Spain indicate that there has been a considerable increase in the uptake of TPMT testing in recent years. There are some data that support routine TPMT testing prior to AZA prescribing for reducing AZA-related adverse events. Key data include evidence in favor of TPMT testing in addition to the current practice of routine monitoring for reducing the number of AZA-related episodes of myelosuppression, averting deaths from neutropenic sepsis and improving health-related quality of life. Further data are needed for determining the cost-effectiveness of routine TPMT testing.
JRC Institute:Institute for Prospective Technological Studies

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