Title: Certification of C-reactive Protein in Reference Material ERM-DA472/IFCC
Authors: ZEGERS IngridCHAROUD-GOT JeanRZYCHON MalgorzataTRAPMANN StefanieSCHIMMEL HeinzEMONS HendrikSCHREIBER WiebkeSHELDON JoannaLINSTEAD SarahMERLINI Giampaolo
Publisher: OPOCE
Publication Year: 2009
JRC N°: JRC50108
ISBN: 978-92-79-11326-0
ISSN: 1018-5593
Other Identifiers: EUR 23756 EN
OPOCE LA-NA-23756-EN-C
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC50108
DOI: 10.2787/21201
Type: EUR - Scientific and Technical Research Reports
Abstract: The production and certification of ERM-DA472/IFCC, a new reference material certified for C-reactive protein (CRP), is described. ERM-DA472/IFCC was characterised using the reference material ERM-DA470 as calibrant. This achieved using a value transfer protocol that can be considered as a reference procedure. the principles used to measure the CRP concentration were immunonephelometry and immunoturbidimetry. The measurements were performed with different platform/reagent combinations (Abbott, Beckmann Immage, BN II, different Hitachi instruments, and Olympus AU640). In total 8 laboratories participated in the value assignment. The certified CRP mass concentration is 41.8 mg/L, the expanded uncertainty (k = 2) 2.5 mg/L.
JRC Institute:Institute for Reference Materials and Measurements

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