Title: Metabolomics: moving towards personalized medicine
Authors: BARALDI EugenioCARRARO SilviaGIORDANO GiuseppeRENIERO FabianoPERILONGO GiorgioZACCHELLO Franco
Citation: Italian journal of pediatrics no. 30 p. 1-4
Publisher: BioMed Central
Publication Year: 2009
JRC N°: JRC50460
ISSN: 0022-3476
URI: http://www.ijponline.net/
http://publications.jrc.ec.europa.eu/repository/handle/JRC50460
Type: Articles in Journals
Abstract: In many fields of medicine there is a growing interest in characterizing diseases at molecular level with a view to developing an individually tailored therapeutic approach. Metabolomics is a novel area that promises to contribute significantly to the characterization of various disease phenotypes and to the identification of personal metabolic features that can predict response to therapies. Based on analytical platforms such as mass spectrometry or NMR-based spectroscopy, the metabolomic approach enables a comprehensive overview of the metabolites, leading to the characterization of the metabolic fingerprint of a given sample. These metabolic fingerprints can then be used to distinguish between different disease phenotypes and to predict a drug's effectiveness and/or toxicity. Several studies published in the last few years applied the metabolomic approach in the field of pediatric medicine. Being a highly informative technique that can be used on samples collected noninvasively (e.g. urine or exhaled breath condensate), metabolomics has appeal for the study of pediatric diseases. Here we present and discuss the pediatric clinical studies that have taken the metabolomic approach.
JRC Institute:Institute for Health and Consumer Protection

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