Title: Analysis of Toxicity Effects from Molecular to Population Level: Circadian Oscillator Case Study
Authors: ZALDIVAR COMENGES Jose'
Publisher: OPOCE
Publication Year: 2009
JRC N°: JRC50491
ISBN: 978-92-79-11603-2
ISSN: 1018-5593
Other Identifiers: EUR 23772 EN
OPOCE LB-NA-23772-EN-C
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC50491
DOI: 10.2788/82036
Type: EUR - Scientific and Technical Research Reports
Abstract: To analyze how toxic effects propagate from molecular to population level, a simple model of a circadian oscillator has been coupled with a cyanobacteria growth model. It has been assumed that the circadian oscillator synchronizes with light-dark environmental conditions and toxicants affect this synchronization reducing the population growth. Then dose-response curves have been developed. The results evidence that to understand toxic effects we have to focus our study on the interactions that a certain compound may have with proteins, and/or DNA, since the result of these interactions will determine the final mode of action at macroscopic level. Therefore an intermediate step for assessing toxic effects has been proposed.
JRC Institute:Institute for Health and Consumer Protection

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