Title: Radioimmunotherapy Is Effective Against High-Inoculum Cryptococcus Neoformans Infection in Mice and Does Not Select for Radiation-Resistant Cryptococcal Cells
Authors: BRYAN R. A.JIANG Z.HUANG X.MORGENSTERN AlfredBRUCHERTSEIFER FrankSELLERS R.CASADEVALL A.DADACHOVA E.
Citation: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY vol. 53 no. 4 p. 1679-1682
Publisher: AMER SOC MICROBIOLOGY
Publication Year: 2009
JRC N°: JRC51183
ISSN: 0066-4804
URI: http://aac.asm.org
http://publications.jrc.ec.europa.eu/repository/handle/JRC51183
DOI: 10.1128/AAC.01334-08
Type: Articles in Journals
Abstract: We investigated the utility of radioimmunotherapy (RIT) in the treatment of experimental cryptococcal infection with high-inoculum and the possibility of RIT treatment selecting for fungal cells with radiation-resistant phenotypes. RIT reduced mortality in high-burden infections, and we found no evidence for the development of radiation-resistant cells.
JRC Institute:Institute for Transuranium Elements

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