Title: Development of Structural Alerts for the In Vivo Micronucleus Assay in Rodents
Authors: BENIGNI RomualdoBOSSA CeciliaTCHEREMENSKAIA OlgaWORTH Andrew
Publisher: OPOCE
Publication Year: 2009
JRC N°: JRC52274
ISSN: 1018-5593
Other Identifiers: EUR 23844 EN
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC52274
Type: EUR - Scientific and Technical Research Reports
Abstract: In vivo mutagenicity and carcinogenicity studies are posing a high demand for test-related resources. Among these studies, the micronucleus test in rodents is the most widely used, as follow up to positive in vitro mutagenicity results. A recent survey of the (Q)SAR models for mutagenicity and carcinogenicity has indicated that no (Q)SAR models for in vivo micronucleus are available in the public domain. Therefore, the development and extensive use of estimation techniques such as (Q)SARs, read-across and grouping of chemicals, promises to have a huge animal saving potential for this endpoint. In this report, we describe the identification of structural alerts for the in vivo micronucleus assay, and provide the list of underlying chemical structures. These structural alerts provide a coarse-grain filter for the preliminary screening of potential in vivo mutagens.
JRC Institute:Institute for Health and Consumer Protection

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