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|Title:||Radiolabelling of TiO2 nanoparticles for radiotracer studies|
|Authors:||ABBAS Kamel; CYDZIK Izabel; DEL TORCHIO Riccardo; FARINA Massimo; FORTI Efrat; GIBSON Peter; HOLZWARTH Uwe; SIMONELLI Federica; KREYLING Wolfgang|
|Citation:||JOURNAL OF NANOPARTICLE RESEARCH vol. 12 no. 7 p. 2435-2443|
|JRC Publication N°:||JRC52481|
|Type:||Articles in Journals|
|Abstract:||Industrially manufactured titanium dioxide nanoparticles have been successfully radiolabelled with 48V by irradiation with a cyclotron-generated proton beam. Centrifugation tests showed that the 48V radio-labels were stably bound within the nanoparticle struc- ture, while X-ray di®raction indicated that no major structural modi¯cations to the nanoparticles resulted from the proton irradiation. In vitro tests of the uptake of cold and radiolabelled nanoparticles using the human cell line Calu-3 showed no signi¯cant di®erence in the uptake between both batches of nanoparticles. The uptake was quanti¯ed by Inductively Coupled Plasma Mass Spectrometry and high resolution °-ray spectrometry for cold and radiolabelled nanoparticles, respectively. These preliminary experiments indicate that al- terations to the nanoparticles' properties introduced by proton bombardment can be controlled to a su±cient extent to allow their use for meaningful biological in-vestigations as radiotracers.|
|JRC Institute:||Institute for Health and Consumer Protection|
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