Title: Radiolabelling of TiO2 nanoparticles for radiotracer studies
Authors: ABBAS KamelCYDZIK IzabelDEL TORCHIO RiccardoFARINA MassimoFORTI EfratGIBSON PeterHOLZWARTH UweSIMONELLI FedericaKREYLING Wolfgang
Citation: JOURNAL OF NANOPARTICLE RESEARCH vol. 12 no. 7 p. 2435-2443
Publisher: SPRINGER
Publication Year: 2010
JRC Publication N°: JRC52481
ISSN: 1388-0764
URI: http://publications.jrc.ec.europa.eu/repository/handle/JRC52481
DOI: 10.1007/s11051-009-9806-8
Type: Articles in Journals
Abstract: Industrially manufactured titanium dioxide nanoparticles have been successfully radiolabelled with 48V by irradiation with a cyclotron-generated proton beam. Centrifugation tests showed that the 48V radio-labels were stably bound within the nanoparticle struc- ture, while X-ray di®raction indicated that no major structural modi¯cations to the nanoparticles resulted from the proton irradiation. In vitro tests of the uptake of cold and radiolabelled nanoparticles using the human cell line Calu-3 showed no signi¯cant di®erence in the uptake between both batches of nanoparticles. The uptake was quanti¯ed by Inductively Coupled Plasma Mass Spectrometry and high resolution °-ray spectrometry for cold and radiolabelled nanoparticles, respectively. These preliminary experiments indicate that al- terations to the nanoparticles' properties introduced by proton bombardment can be controlled to a su±cient extent to allow their use for meaningful biological in-vestigations as radiotracers.
JRC Institute:Institute for Health and Consumer Protection

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