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|Title:||Thresholds of Toxicological Concern for Endocrine Active Substances in the Aquatic Environment|
|Authors:||GROSS Melanie; DAGINNUS Klaus; DEVILLER Geneviève; DE WOLF Watze; DUNGEY Stephen; GALLI Corrado; GOURMELON Anne; JACOBS Miriam; MATTHIESSEN Peter; MICHELETTI Christian; NESTMANN Earle; PAVAN Manuela; PAYA PEREZ Ana; RATTE Hans-Toni; SAFFORD Bob; SOKULL-KLUETTGEN Birgit; STOCK Frauke; STOLZENBERG Hans-Christian; WHEELER James; WILLUHN Marc; WORTH Andrew; ZALDIVAR COMENGES Jose'; CRANE Mark|
|Citation:||Integrated Environmental Assessment and Management vol. 6 no. 1 p. 2-11|
|Type:||Articles in Journals|
|Abstract:||The threshold of toxicological concern (TTC) concept proposes that an exposure threshold value can be derived for chemicals, below which no significant risk to human health or the environment is expected. This concept goes further than setting acceptable exposure levels for individual chemicals, because it attempts to set a de minimis value for chemicals, including those of unknown toxicity, by taking the chemical's structure or mode of action (MOA) into consideration. This paper examines the use of the TTC concept for endocrine active substances (EAS) with an estrogenic MOA. A case study formed the basis for a workshop of regulatory, industry and academic scientists held to discuss the use of the TTC in aquatic environmental risk assessment. The feasibility and acceptability, general advantages and disadvantages, and the specific issues that need to be considered when applying the TTC concept for EAS in risk assessment were addressed. Issues surrounding the statistical approaches used to derive TTCs were also discussed. This paper presents discussion points and consensus findings of the workshop.|
|JRC Institute:||Institute for Health and Consumer Protection|
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